New Data from Ciforadenant Phase 1b/2 Clinical Study Presented at ESMO Virtual Congress 2020
Data is part of Genentech’s MORPHEUS umbrella program and covers patients with resistant/refractory NSCLC treated with ciforadenant in combination with atezolizumab
Results consistent with prior studies, showing prolonged survival compared to chemotherapy and favorable safety data
“In this small study in non-small cell lung cancer (NSCLC), more patients treated with ciforadenant and atezolizumab had longer disease control and overall survival as compared to chemotherapy,” said
The ESMO poster (#1315P) covers results from the MORPHEUS Phase 1b/2 study of ciforadenant in combination with Genentech’s Tecentriq® (atezolizumab), compared to a docetaxel chemotherapy control arm, as a second- or third-line therapy in patients with NSCLC who had previously failed on treatment with a platinum-containing chemotherapy regimen and a PD-L1/PD-1 checkpoint inhibitor. The data includes results from 15 patients treated in the combination arm and 14 patients treated in the control arm. The recently described adenosine gene signature biomarker was not utilized in this study. The key data related to ciforadenant from the poster include:
- In the ciforadenant and atezolizumab combination arm (N=15), 11 patients had response assessment. Of these, one patient achieved a long-term, ongoing partial response (PR) of 13+ months and six patients had long-term, stable disease (SD) including one ongoing SD of 15+ months. In total, four patients (one with a PR and three patients with SD) had disease control of 6+ months, including two patients that are still on therapy.
- In the docetaxel chemotherapy control arm (N=14), three patients achieved short-term PR (4, 7 and 9 months), two patients achieved disease control beyond six months and all patients have discontinued treatment.
- The median overall survival (OS) was 11.5 months in the ciforadenant and atezolizumab combination arm, compared to 9.4 months in the control arm.
- The safety profile in both arms was as expected: no patients receiving ciforadenant and atezolizumab combination had Grade 5 adverse events or adverse event that led to treatment withdrawal. Of the patients receiving docetaxel chemotherapy, 1 experienced a Grade 5 adverse event and 3 had adverse events that led to treatment withdrawal. The overall treatment related adverse event rate was 67% in the combination arm, compared to 93% in the control arm.
To-date, more than 300 patients have been treated with ciforadenant across multiple clinical studies and the Company’s most advanced development program with ciforadenant is for treatment of patients with advanced refractory renal cell carcinoma (RCC). Corvus presented the latest data on RCC patients treated with ciforadenant, along with data supporting the Adenosine Gene Signature’s ability to identify patients likely to respond to treatment with ciforadenant, at the ASCO20 Virtual Scientific Program in
About Genentech’s MORPHEUS Platform
The MORPHEUS platform consists of multiple, global, open-label, randomized, umbrella Phase 1b/2 trials designed to accelerate the development of combinations for several indications by identifying early signals and establishing proof-of-concept clinical data.
About Corvus Pharmaceuticals
Tecentriq® (atezolizumab) is a registered trademark of
Ciforadenant (CPI-444) is a small molecule, oral, checkpoint inhibitor designed to disable a tumor’s ability to subvert attack by the immune system by blocking the binding of adenosine in the tumor microenvironment to the A2A receptor. Adenosine, a metabolite of ATP (adenosine tri-phosphate), is produced within the tumor microenvironment where it may bind to the adenosine A2A receptor present on immune cells and block their activity. CD39 and CD73 are enzymes on the surface of tumor cells and immune cells. These enzymes work in concert to convert ATP to adenosine.
Adenosine Gene Signature
The adenosine gene signature is a biomarker that reflects adenosine induced immunosuppression in the tumor. These genes express chemokines that recruit myeloid cells including immunosuppressive tumor associated myeloid cells, which are thought to mediate resistance to anti-PD-(L)1 treatment. To date, in our clinical trial of renal cell cancer, this biomarker has been associated with a higher rate of response to ciforadenant. It is anticipated that the adenosine gene signature may also be useful in identifying patients most likely to respond in NSCLC.
This press release contains forward-looking statements, including statements related to the potential safety and efficacy of ciforadenant, CPI-006, and CPI-818, the Company’s ability to develop and advance product candidates into and successfully complete clinical trials, the utility of the Adenosine Gene Signature and the timing of certain product development milestones. All statements other than statements of historical fact contained in this press release are forward-looking statements. These statements often include words such as “believe,” “expect,” “anticipate,” “intend,” “plan,” “estimate,” “seek,” “will,” “may” or similar expressions. Forward-looking statements are subject to a number of risks and uncertainties, many of which involve factors or circumstances that are beyond the Company’s control. The Company’s actual results could differ materially from those stated or implied in forward-looking statements due to a number of factors, including but not limited to, risks detailed in the Company’s Quarterly Report on Form 10-Q for the quarter ended
Chief Financial Officer
Source: Corvus Pharmaceuticals, Inc.